Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

16
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
16
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.6K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.6K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

21
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
21
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

17
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
17
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

948
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
948
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

17
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
17

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Collection for Primary HPV Testing: Acceptability in a Large Urban Emergency Department.

Annals of emergency medicine·2024
Same author

Maladaptive behaviors in disasters: case study evaluation of Hurricane Hugo, Hurricane Katrina and the Haiti Earthquake.

Frontiers in public health·2024
Same author

The 2023 Model Core Content of Disaster Medicine.

Prehospital and disaster medicine·2023
Same author

Hyperkalemia and Electrocardiogram Manifestations in End-Stage Renal Disease.

International journal of environmental research and public health·2022
Same author

A framework for the design and implementation of Stop the Bleed and public access trauma equipment programs.

Journal of the American College of Emergency Physicians open·2022
Same author

Recommended Process Outcome Measures for Stop the Bleed Education Programs.

AEM education and training·2021

Related Experiment Video

Updated: Apr 20, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

1.7K

Elevated lipase without pancreatitis in infectious colitis.

Dick C Kuo1, Carli Calderone1, Ira Nemeth1

  • 1Department of Medicine, Section of Emergency Medicine, Baylor College of Medicine, Houston, Texas.

The Journal of Emergency Medicine
|December 3, 2014
PubMed
Summary

Elevated lipase levels can occur in conditions other than pancreatitis, such as infectious colitis. Emergency physicians should consider a broader differential diagnosis for elevated lipase to avoid unnecessary hospital admissions.

Keywords:
colitislipasepancreatitis

More Related Videos

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

6.0K
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

10.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

1.7K
Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

6.0K
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

10.1K

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Emergency Medicine

Background:

  • Elevated lipase is a common indicator for diagnosing pancreatitis.
  • However, lipase can also be elevated in other conditions affecting the pancreas.
  • This case explores a rare association between elevated lipase and infectious colitis.

Observation:

  • A 65-year-old woman presented with abdominal pain, diarrhea, and weight loss.
  • Her laboratory results showed a markedly elevated lipase level.
  • Imaging revealed infectious colitis without evidence of pancreatitis.

Findings:

  • This is the first reported case of elevated lipase in a patient with infectious colitis.
  • The patient's elevated lipase normalized after treatment for infectious colitis.
  • Pancreatic inflammation was ruled out through imaging.

Implications:

  • Emergency physicians must consider non-pancreatic causes of elevated lipase.
  • Broadening the differential diagnosis can prevent unnecessary admissions for suspected pancreatitis.
  • This case highlights the importance of comprehensive evaluation in patients with elevated lipase.