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A genetic basis for tumour suppression.

E J Stanbridge¹

¹Department of Microbiology and Molecular Genetics, California College of Medicine, University of California, Irvine 92717.

Ciba Foundation Symposium

|January 1, 1989

Summary

Somatic cell hybridization reveals tumor suppression

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Area of Science:

Cancer Genetics
Cell Biology
Molecular Oncology

Background:

Somatic cell hybridization established tumor suppression and its genetic basis.
Microcell-mediated chromosome transfer is a refinement for identifying tumor suppressor genes.

Purpose of the Study:

To investigate tumor suppression using microcell hybridization in various cancer cell lines.
To explore the role of oncogenes in tumor suppression and tumorigenic conversion.

Main Methods:

Somatic cell hybridization and microcell-mediated chromosome transfer.
Introduction of activated c-Ha-ras oncogene into HaCaT keratinocytes.

Main Results:

Demonstrated tumor suppression in hybrids of HeLa cells and fibroblasts.
Studied tumor suppression in Wilms' tumor, retinoblastoma, and osteosarcoma cells.
Investigated oncogene-induced transformation in human keratinocytes.

Conclusions:

Tumor suppression has a genetic basis, potentially involving tumor suppressor genes.
The interaction between oncogenes and tumor suppressor mechanisms is complex.
Human cell genomic stability influences oncogene-induced transformation.

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