Related Experiment Video
Updated: Apr 20, 2026
Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: A resting-state
Xiaofen Ma1, Shumei Li2, Junzhang Tian2
1Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China.
Objective:
We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain.
Methods:
With fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions.
Results:
IBS patients showed decreased ALFF values in the left superior frontal gyrus, right hippocampus, right middle frontal gyrus, bilateral postcentral, and right superior temporal pole, while increased ALFF values in the left median cingulate and left calcarine. There was significant correlation between ALFF values in the altered regions and duration of disease in IBS. FC analysis revealed the increased connectivity between cingulate and frontal cortex in IBS.
Conclusions:
Our findings could provide both regional and brain connectivity spontaneous neuronal activity properties in IBS.
Significance:
Our study may lead to a better understanding of intrinsic functional architecture of brain activity in IBS and highlight the potential for using the ALFF and FC metrics as a disease biomarker.
More Related Videos
07:56Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
Published on: June 24, 2025
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
Related Concept Videos
01:23Irritable Bowel Syndrome
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:14Brain Imaging
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...