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Updated: Apr 20, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Weight fluctuation during childhood and cardiometabolic risk at young adulthood
Daniëlla van de Langenberg1, Trynke Hoekstra2, Jos W R Twisk2
1Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, The Netherlands.
Insights
Weight fluctuation in early childhood predicts adult overweight in girls. For boys, the trend of weight change, not fluctuation, is linked to adult overweight. These findings highlight early life weight patterns for future health.
Area of Science:
- Pediatric Health
- Cardiovascular Health
- Obesity Research
Background:
- Early childhood weight patterns may influence long-term health.
- Understanding weight fluctuation's impact is crucial for preventative strategies.
Purpose of the Study:
- To investigate the association between weight fluctuation between ages 2-6 and adult weight measures and cardiometabolic risk.
- To determine if early childhood weight variability predicts later health outcomes.
Main Methods:
- Assessed weight fluctuation using BMI SD scores in 282 children (166 girls, 116 boys) from the Terneuzen Birth Cohort.
- Measured cardiometabolic risk factors and weight in young adulthood.
- Related individual weight variation scores to adult BMI and metabolic syndrome components.
Main Results:
- Greater weight fluctuation in early childhood was significantly associated with higher adult weight measures in girls.
- Weight fluctuation was not significantly linked to adult metabolic syndrome in girls.
- For boys, weight fluctuation was not associated with adult weight, but weight slope predicted adult overweight.
Conclusions:
- Early childhood weight fluctuations predict adult overweight in girls.
- Weight trends (slope) rather than fluctuation predict adult overweight in boys.
- Findings suggest sex-specific relationships between early weight patterns and adult health.
Objectives:
To test the hypothesis that greater weight fluctuation between 2 and 6 years is associated with an increase in weight measures (such as body mass index [BMI]) and cardiometabolic risk in young adulthood.
Study Design:
Weight fluctuation (determined by BMI SD scores) was measured at least 3 times between the ages of 2 and 6 years in 166 girls and 116 boys from the Terneuzen Birth Cohort. Cardiometabolic risk factors in young adulthood include components of the metabolic syndrome and weight. The extent of weight fluctuation was determined by assessing each individual's SE (or variation) around each individual's linear regression slope (or weight slope). The obtained variation scores were subsequently related to adult BMI, other weight measures, and cardiometabolic risk factors.
Results:
In girls, greater weight fluctuation between 2 and 6 years was statistically significantly related to greater adult weight measures (1.08; 95% CI 1.01-1.15) and nonsignificantly with the metabolic syndrome. For boys weight fluctuation was not associated with adult weight (1.04; 95% CI 0.97-1.11), but weight slope was statistically significantly associated with adult overweight.
Conclusions:
The results suggest that weight fluctuations during early childhood are predictive for adult overweight in girls. For boys weight slope instead of weight fluctuation is predictive for adult overweight.
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