Hemostatic sponge effect on adhesion prevention in a porcine model

Area of Science:

• Gynecological Surgery
• Surgical Adhesion Prevention
• Biomaterials in Medicine

Background:

• Postsurgical adhesions are a common complication in gynecological procedures.
• Preventive strategies are crucial to improve patient outcomes.
• An absorbable hemostatic collagen sponge (HCS) was investigated for its adhesion-reducing potential.

Purpose of the Study:

• To evaluate the efficacy of an absorbable hemostatic collagen sponge (HCS) in preventing postsurgical gynecological adhesions.
• To assess the impact of HCS on adhesion incidence, severity, inflammation, and fibrosis in a porcine model.

Main Methods:

• A porcine model underwent uterine horn myotomy and deserosation.
• Animals were randomized into HCS application and control groups.
• Adhesions were evaluated macroscopically and microscopically after a 5-month follow-up.

Main Results:

• HCS did not significantly alter the incidence of adhesion-free animals.
• Adhesion severity was significantly reduced with HCS in the laparotomy group (P < 0.01).
• HCS application significantly decreased inflammation scores in the laparoscopic approach (P < 0.01).
• Fibrosis patterns varied, with reduction in the laparoscopic group and increase in the laparotomy group.

Conclusions:

• Absorbable hemostatic collagen sponge (HCS) is safe for gynecological use.
• HCS demonstrated a reduction in adhesion severity and inflammation, depending on the surgical approach.
• Further research may optimize HCS application for enhanced adhesion prevention.