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Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
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Hypnotic use and fatigue in multiple sclerosis.

Tiffany J Braley1, Benjamin M Segal2, Ronald D Chervin3

  • 1Department of Neurology and Multiple Sclerosis Center, University of Michigan, Ann Arbor, MI, USA; Department of Neurology and Sleep Disorders Center, University of Michigan, Ann Arbor, MI, USA.

Sleep Medicine
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Hypnotic use is common in multiple sclerosis (MS) patients, with over-the-counter (OTC) diphenhydramine products frequently used. This usage is linked to increased daytime fatigue in individuals with MS.

Keywords:
DiphenhydramineFatigueFatigue severity scaleHypnoticInsomniaMSMultiple sclerosisSleepiness

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Area of Science:

  • Neurology
  • Sleep Medicine
  • Pharmacology

Background:

  • Sleep disturbances and fatigue are prevalent in multiple sclerosis (MS).
  • Understanding hypnotic medication use patterns in MS is limited.
  • The association between hypnotic use and fatigue in MS requires investigation.

Purpose of the Study:

  • To determine the prevalence of prescription and over-the-counter (OTC) hypnotic use in MS patients.
  • To examine the relationship between hypnotic use and fatigue severity in individuals with MS.

Main Methods:

  • Retrospective analysis of medical records and survey data from 190 MS patients.
  • Assessment of sleep quality, quantity, sleepiness, insomnia, and fatigue using validated questionnaires.
  • Statistical analysis including correlation and regression to evaluate hypnotic use and fatigue.

Main Results:

  • Nearly half (47%) of MS patients reported occasional or more frequent hypnotic use.
  • Over-the-counter diphenhydramine-containing products were the most commonly used hypnotics (25%).
  • Hypnotic use, particularly OTC diphenhydramine, correlated significantly with increased daytime fatigue (FSS scores).

Conclusions:

  • Hypnotic use is highly prevalent among individuals with multiple sclerosis.
  • Carryover effects from hypnotics, especially OTC diphenhydramine, may contribute to daytime fatigue in MS patients.
  • Further research into safer sleep management strategies for MS patients is warranted.