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The role of Mycoplasma and Ureaplasma in adverse pregnancy outcomes

Amy P Murtha1, James M Edwards2

  • 1Department of Obstetrics and Gynecology, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA; Division of Maternal Fetal Medicine, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA; Department of Pediatrics, Duke University Medical Center, 2608 Erwin Road, Suite 200, Durham, NC 27705, USA.

Obstetrics and Gynecology Clinics of North America
|December 3, 2014
PubMed

Insights

Genital mycoplasmas, including Mycoplasma and Ureaplasma, are linked to adverse perinatal outcomes like preterm birth and neonatal infections. Further research is needed to distinguish the specific effects of each species.

Area of Science:

  • Reproductive Health
  • Microbiology
  • Obstetrics

Background:

  • Genital mycoplasmas are common in vaginal flora across diverse populations.
  • These bacteria are implicated in negative pregnancy and birth outcomes.
  • Inflammation caused by Mycoplasma and Ureaplasma spp. is a potential mechanism.

Purpose of the Study:

  • To review existing literature on the role of genital mycoplasmas in perinatal complications.
  • To provide evidence supporting the association between these microbes and adverse outcomes.
  • To highlight the need for species-specific research.

Main Methods:

  • Literature review of studies investigating genital mycoplasmas and perinatal outcomes.
  • Analysis of evidence linking Mycoplasma and Ureaplasma species to pregnancy complications.
  • Synthesis of findings on infectious complications and neonatal infections.

Main Results:

  • Genital mycoplasmas are frequently detected in the vaginal microbiome.
  • Evidence supports their role in spontaneous preterm birth and PPROM (preterm rupture of membranes).
  • Association with post-delivery infections and neonatal infections is also noted.

Conclusions:

  • Genital mycoplasmas contribute to significant perinatal complications.
  • Differentiating the impact of specific Mycoplasma and Ureaplasma species is crucial for future research and clinical management.
  • Understanding species-specific roles may lead to targeted interventions.
Keywords:
Bronchopulmonary dysplasiaChorioamnionitisEndometritisGenital mycoplasmaMycoplasmaPreterm birthUreaplasma

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