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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
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Pulmonary tuberculosis induces a systemic hypercoagulable state.

Liesbeth M Kager1, Dana C Blok1, Ivar O Lede2

  • 1Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

The Journal of Infection
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Pulmonary tuberculosis (TB) creates a systemic hypercoagulable state, increasing blood clot risk. This study found altered pro- and anticoagulant mechanisms in TB patients compared to healthy individuals.

Keywords:
BronchoscopyCoagulationFibrinolysisLung inflammationTuberculosis

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Pulmonology

Background:

  • Tuberculosis (TB) is a significant global health concern, with Bangladesh being a highly affected country.
  • Understanding the impact of pulmonary TB on the body's clotting mechanisms is crucial for patient management.

Purpose of the Study:

  • To investigate the effects of primary and recurrent pulmonary TB on procoagulant and anticoagulant pathways.
  • To compare coagulation status in TB patients with healthy controls and examine coagulation at the infection site.

Main Methods:

  • Prospective analysis of coagulation in 64 primary TB, 11 recurrent TB patients, and 37 healthy controls in Chittagong, Bangladesh.
  • Measurement of plasma markers for coagulation activation (thrombin-antithrombin complexes, D-dimer, fibrinogen) and inhibition (antithrombin, protein C, protein S, protein C inhibitor).
  • Analysis of coagulation in bronchoalveolar lavage fluid (BALF) from infected and unaffected lung segments in a subset of patients.

Main Results:

  • Both primary and recurrent pulmonary TB were linked to a systemic procoagulant state.
  • Elevated markers of coagulation activation and reduced levels of key anticoagulants were observed in TB patients.
  • Coagulation activation was not detected in BALF from the primary infection site in some patients and did not correlate with TB biomarkers.

Conclusions:

  • Pulmonary TB is associated with a systemic hypercoagulable state.
  • The findings suggest a potential link between TB and increased risk of thrombotic events.