Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
03:42

Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis

Published on: March 15, 2024

1.5K

A systematic review of the extra-pancreatic infectious complications in acute pancreatitis

Lisa A Brown1, Todd A Hore1, Anthony R J Phillips1

  • 1The Department of Surgery, The University of Auckland, Auckland, New Zealand.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|December 3, 2014
PubMed
Abstract

Insights

A third of acute pancreatitis patients develop extra-pancreatic infections, most commonly respiratory infections or bacteremia. Early detection and treatment are crucial to prevent progression to infected pancreatic necrosis.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Extra-pancreatic infections are known to increase morbidity in acute pancreatitis.
  • The incidence and relationship of these complications with infected pancreatic necrosis remain unclear.
  • Non-enteric bacteria in pancreatic necrosis suggest alternative infection sources.

Purpose of the Study:

  • To systematically review the incidence of extra-pancreatic infectious complications in acute pancreatitis.
  • To determine the timing of these complications.
  • To assess their association with pancreatitis severity and mortality.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searches conducted in Ovid MEDLINE, Embase, and Cochrane Libraries.
  • Included studies focused on "Pancreatitis" AND "Infection" AND ("Complication" OR "Outcome").

Main Results:

  • 19 studies involving 1741 patients were analyzed.
  • The incidence of extra-pancreatic infectious complications was 32% (95% CI 23-41%).
  • Respiratory infections (9.2%) and bacteremia (8.4%) were most frequent; no association with pancreatitis severity or mortality was found.

Conclusions:

  • This is the first systematic review on extra-pancreatic infectious complications in acute pancreatitis.
  • Approximately one-third of patients experience these complications.
  • Vigilance and prompt treatment are essential to prevent progression to infected pancreatic necrosis.
Keywords:
ComplicationsInfectionMeta-analysisOutcomePancreatitisSeverity

More Related Videos

Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis04:01

Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis

Published on: September 8, 2022

3.2K
Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction12:34

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Published on: January 3, 2020

17.7K

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
16
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.6K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
21
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
541
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
17