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05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
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The interaction between cytomegalovirus and the human immune system
Ineke J M ten Berge1, René A W van Lier2
1Department of Experimental and Clinical Immunology and Renal Transplant Unit, Academic Medical Centre, Amsterdam, The Netherlands.
Immunology Letters
|December 3, 2014
Summary
Studying human antiviral immunity is difficult, but cytomegalovirus (CMV) infection in organ transplant recipients offers a unique window. Research focuses on understanding the immune response to CMV, aiding vaccine development.
Area of Science:
- Immunology
- Virology
- Transplantation
Background:
- Standardizing human antiviral immunity studies is challenging.
- Cytomegalovirus (CMV) infection in organ transplant recipients provides a unique, precisely timed infection model.
- CMV's evolutionary interaction with the human immune system and its immunogenicity make it a key research focus.
Purpose of the Study:
- To review research on the human immune response to cytomegalovirus (CMV).
- To highlight the relevance of studying CMV immunity for potential vaccine development.
- To consolidate findings from specific immunology departments.
Main Methods:
- Review of existing studies on antiviral immunity.
- Focus on cytomegalovirus (CMV) infection in transplant recipients.
- Analysis of immune responses within specific research departments.
Main Results:
- Cytomegalovirus (CMV) infection in transplant recipients allows for precise study of antiviral immunity.
- CMV's characteristics make it a valuable model for understanding human immune responses.
- Research highlights the need for interventions like vaccines.
Conclusions:
- Studying cytomegalovirus (CMV) immunity in transplant recipients is crucial for advancing antiviral strategies.
- The findings underscore the importance of continued research in experimental and clinical immunology.
- This work provides an overview of relevant studies conducted at AMC and Sanquin.
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