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JNK suppresses tumor formation via a gene-expression program mediated by ATF2

Malgorzata Gozdecka1, Stephen Lyons2, Saki Kondo3

  • 1Department of Cell Regulation, CRUK Manchester Institute, Paterson Building, University of Manchester, Manchester M20 4BX, UK; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Cell Reports
|December 3, 2014
PubMed
Summary

Activating transcription factor 2 (ATF2) suppresses liver cancer formation by regulating gene expression. This JNK-ATF2 pathway is often lost in human cancers, suggesting its restoration could be a therapeutic strategy.

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