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Related Experiment Videos

Herpes simplex retinitis in the mouse. Clinicopathologic correlations.

S W Cousins1, A Gonzalez, S S Atherton

  • 1Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.

Investigative Ophthalmology & Visual Science
|July 1, 1989
PubMed
Summary

Herpes simplex virus type 1 infection in mice causes retinitis and retinal necrosis. Inflammation in the uninfected eye correlates with virus levels, validating this model for studying herpetic retinitis.

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Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Background:

  • Herpes simplex virus type 1 (HSV-1) can cause ocular infections.
  • Herpetic retinitis, a severe inflammation of the retina, can lead to vision loss.
  • Understanding the pathogenesis of herpetic retinitis is crucial for developing effective treatments.

Purpose of the Study:

  • To characterize the clinical and pathological features of HSV-1 induced retinitis in a mouse model.
  • To correlate clinical findings with viral load and microscopic pathology.
  • To establish a reliable animal model for studying herpetic retinitis.

Main Methods:

  • BALB/c mice were inoculated with HSV-1 in the anterior chamber.
  • Ophthalmoscopy and fundus photography were used for clinical assessment.

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  • Microscopic examination and viral titration were performed.

    • Main Results:

    • A three-phase disease progression was observed: acute retinitis, retinal necrosis, and resolution.
    • Clinical retinitis in the contralateral eye correlated with viral titers in that eye.
    • Microscopic findings supported the clinical observations of disease phases.

    Conclusions:

    • This mouse model effectively replicates the clinical, virologic, and immunologic aspects of herpetic retinitis.
    • The model allows for detailed analysis of disease progression and host response.
    • It serves as a valuable tool for investigating therapeutic strategies against HSV-1 ocular disease.