Related Experiment Video
Updated: Apr 20, 2026
10:47
Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
Published on: April 14, 2011
17.5K
Many respiratory viruses have temporal association with meningococcal disease
J A Castro-Rodriguez1, L Jakubson2, O Padilla3
1Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Allergologia Et Immunopathologia
|December 3, 2014
Summary
Respiratory viruses, including RSV, are linked to meningococcal disease (MNG) outbreaks in Chile. This study confirms associations between multiple viruses and MNG rates across different regions and age groups.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Previous research indicated a link between influenza and meningococcal disease (MNG).
- However, studies examining the association with multiple respiratory viruses were lacking.
Purpose of the Study:
- To investigate the temporal association between various respiratory viruses and meningococcal disease in Chile.
- To analyze these associations across different age groups and regions.
Main Methods:
- Utilized data from Chile (2000-2005) on confirmed cases of MNG and respiratory viruses (influenza A/B, parainfluenza, adenovirus, RSV).
- Analyzed data by epidemiological week, age range, and region.
- Employed transfer function models to assess MNG rates.
Main Results:
- Over 1000 MNG cases and over 34,000 respiratory virus cases were recorded.
- Respiratory Syncytial Virus (RSV) showed the strongest temporal association, preceding MNG by one week.
- Other viruses like parainfluenza, influenza B, adenovirus, and influenza A also demonstrated temporal associations with MNG.
Conclusions:
- Meningococcal disease rates in Chile are temporally associated with all studied respiratory viruses.
- These associations exhibit variability based on age group and geographical region.
More Related Videos
10:03Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
7.9K
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
3.4K
Related Concept Videos
01:18Viral Meningitis
165
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
165
01:22Bacterial Meningitis I: Introduction
3
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
3
01:26Bacterial Meningitis II: Pathophysiology
2
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
2
01:27Influenza
57
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
57
01:25Arboviral Encephalitis
52
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
52
01:25Mechanism of Antibiotic Resistance in MRSA
165
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
165