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Exercise training attenuates the myocardial dysfunction induced by endotoxin.

P M DeBlieux1, K H McDonough, R W Barbee

  • 1Department of Physiology, Louisiana State University Medical Center, New Orleans 70113.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1989
PubMed
Summary

Exercise training protects the heart from endotoxin-induced dysfunction by maintaining beta-adrenergic receptor function and lowering harmful catecholamine levels. This study demonstrates exercise

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Endocrinology

Background:

  • Endotoxin administration can cause myocardial dysfunction.
  • The protective effects of exercise training against endotoxin-induced cardiac issues are not fully understood.

Purpose of the Study:

  • To investigate whether exercise training provides protection against endotoxin-induced myocardial dysfunction.
  • To explore the mechanisms underlying this potential protective effect.

Main Methods:

  • Animals were divided into trained and sedentary groups, receiving either saline or endotoxin.
  • Hemodynamic parameters, plasma catecholamines, and myocardial performance were assessed.
  • Isolated myocyte adenosine 3',5'-cyclic monophosphate (cAMP) production in response to isoproterenol was measured.

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Main Results:

  • Trained endotoxin-injected animals (TE) exhibited lower plasma catecholamine levels compared to sedentary endotoxin-injected animals (SE).
  • Cardiac work was reduced less in TE (32%) than in SE (45%) following endotoxin administration.
  • Myocytes from TE maintained adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in response to isoproterenol, unlike those from SE.

Conclusions:

  • Exercise training appears to protect against endotoxin-induced myocardial dysfunction.
  • This protection may be mediated by blunted catecholamine responses and preserved beta-adrenergic receptor-adenylate cyclase system function.
  • Treadmill exercise training enhances cardiovascular resilience to endotoxin challenge.