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Updated: Apr 20, 2026
06:06
Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
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[Epidemiology of Streptococcus pyogenes infections in developing countries]
Ph Minodier1, R Laporte1, S Miramont1
1Service des urgences pédiatriques, hôpital Nord, Chemin-des-Bourrely, 13015 Marseille, France.
Summary
Group A streptococcal (GAS) infections disproportionately impact developing nations, causing most global pharyngitis, invasive diseases, and deaths. Higher frequency and mortality rates are observed in these regions, underscoring a significant public health challenge.
Area of Science:
- Infectious Diseases
- Epidemiology
- Microbiology
Context:
- Group A streptococcal (GAS) infections are a significant global health concern, particularly prevalent in developing countries.
- Epidemiological data on GAS infections in these regions remain incomplete, despite their high disease burden.
Purpose:
- To summarize the epidemiology of Group A streptococcal infections, focusing on their impact in developing countries.
- To highlight the global burden of rheumatic heart disease and acute post-streptococcal glomerulonephritis linked to GAS.
Summary:
- In 2005, developing countries accounted for 90% of symptomatic pharyngitis, 96% of invasive GAS diseases, and 97% of GAS-related deaths.
- Clinical presentations of invasive GAS infections are similar to developed countries, but with higher incidence, mortality, and emm type diversity.
- Rheumatic heart disease affects 15.6-19.6 million people globally, with 282,000 new cases and substantial mortality annually. Acute post-streptococcal glomerulonephritis incidence is high in developing nations.
Impact:
- The findings underscore the critical need for improved surveillance and control strategies for GAS infections in developing countries.
- The World Heart Federation's goal to reduce rheumatic heart disease burden by 25% by 2025 highlights the urgency of addressing GAS-related sequelae.
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