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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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BSA/polyelectrolyte core-shell nanoparticles for controlled release of encapsulated ibuprofen
1Department of Physical Chemistry and Materials Science, Faculty of Science and Informatics, University of Szeged, Aradi Vt. 1, Szeged H-6720, Hungary.
Colloids and Surfaces. B, Biointerfaces
|December 3, 2014
Summary
Core-shell nanoparticles using bovine serum albumin (BSA) were created for drug delivery. These BSA nanoparticles effectively encapsulate and control the release of ibuprofen (IBU), reducing release by 40% in layered structures.
Area of Science:
- Materials Science
- Biotechnology
- Pharmaceutical Science
Background:
- Bovine serum albumin (BSA) is a versatile protein for developing drug delivery systems.
- Core-shell nanoparticles offer enhanced stability and controlled release properties for therapeutic agents.
- Low solubility drugs pose challenges for effective drug delivery and require advanced carrier systems.
Purpose of the Study:
- To develop BSA-based core-shell nanoparticles for drug transportation.
- To investigate the structural changes of BSA during nanoparticle synthesis.
- To evaluate the controlled release of ibuprofen (IBU) from these nanoparticles.
Main Methods:
- Core-shell nanoparticle synthesis using electrostatic interactions between BSA, poly(sodium-4-styrene)sulphonate (PSS), and chitosan (Chit).
- Characterization of nanoparticle structure and size using Fourier Transform Infrared (FT-IR) spectroscopy, Dynamic Light Scattering (DLS), and Small-Angle X-ray Scattering (SAXS).
- In vitro drug release studies using a Franz diffusion cell at physiological pH and temperature.
Main Results:
- BSA's secondary structure changed from ordered to random coil upon ibuprofen addition, with subsequent restoration by polyelectrolyte shells.
- Nanoparticle size and structure were significantly influenced by pH changes.
- Controlled release of ibuprofen was achieved, with a 40% reduction in release from two-layered composites compared to BSA alone.
Conclusions:
- BSA-based core-shell nanoparticles are effective carriers for ibuprofen delivery.
- The polyelectrolyte shells play a crucial role in stabilizing the BSA structure and controlling drug release.
- These nanoparticles demonstrate potential for improving the delivery of poorly soluble drugs.
Keywords:
Bovine serum albuminControlled releaseCore–shell nanoparticlesIbuprofenKinetic modelsPolyelectrolytesMore Related Videos
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