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Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis
Marco Antonio dos Anjos Corvo1, Claudia Alessandra Eckley1, Luis Vicente Rizzo2
1Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil; Department of Otorhinolaryngology, Hospital Central da Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Introduction:
Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux.
Objective:
To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls.
Methods:
This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations.
Results:
The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls.
Conclusion:
Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group.
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