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Related Concept Videos

Hepatitis01:25

Hepatitis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

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Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
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Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
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Hepatitis C virus and lymphoma.

Semra Paydas1

  • 1Cukurova University, Faculty of Medicine, Dept of Oncology, 01330 Adana, Turkey.

Critical Reviews in Oncology/Hematology
|December 3, 2014
PubMed
Summary

Hepatitis C virus (HCV) infection is linked to B-cell non-Hodgkin lymphomas (B-NHL). Chronic HCV, detected by HCV-RNA, is crucial for lymphomagenesis, with varied treatment approaches based on lymphoma grade.

Keywords:
Aggressive/indolent lymphomaHCVHCV prognostic scoreLymphomaRituximab, Immuno-chemotherapySustained viral response

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Area of Science:

  • Hepatology
  • Oncology
  • Virology

Background:

  • Hepatitis C virus (HCV) is a significant global health concern.
  • HCV infection is associated with liver cirrhosis and hepatocellular carcinoma.
  • Epidemiological studies demonstrate a link between HCV and B-cell non-Hodgkin lymphomas (B-NHL).

Purpose of the Study:

  • To review the association between Hepatitis C virus and B-cell non-Hodgkin lymphomas.
  • To discuss diagnostic methods and management strategies for HCV-related NHL.

Main Methods:

  • Literature review of epidemiological studies and clinical reports.
  • Analysis of diagnostic techniques for HCV detection in NHL patients.
  • Evaluation of treatment outcomes for HCV-related lymphomas.

Main Results:

  • A confirmed association exists between chronic HCV infection and the development of B-NHL.
  • HCV-RNA testing is more sensitive than antibody tests for detecting this association.
  • Geographical variability in HCV-related NHL prevalence is observed.
  • Chronic infection, not cleared infection, is implicated in lymphomagenesis.

Conclusions:

  • The management of HCV-related NHL requires tailored approaches.
  • Antiviral therapy may suffice for low-grade or asymptomatic lymphomas.
  • High-grade lymphomas necessitate immuno-chemotherapy, despite potential hepatic toxicity.