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Related Experiment Video

Updated: Apr 20, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

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Published on: April 3, 2013

Neurobiology: Reelin mediates form and function.

Tae-Ju Park¹, Tom Curran¹

¹The Children's Hospital of Philadephia Research Institute, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.

Current Biology : CB

|December 3, 2014

Summary

Reelin protein guides brain development by controlling neuronal migration and specifying dendritic compartmentalization. Its signaling pathway enriches ion channels in dendritic tufts, impacting neuronal function.

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Reelin is crucial for neuronal migration and laminar structure formation in the developing brain.
Understanding Reelin's precise molecular mechanisms is essential for comprehending brain development.

Purpose of the Study:

To investigate a novel role for Reelin signaling beyond neuronal migration.
To elucidate the function of Reelin in specifying dendritic compartmentalization.

Main Methods:

Analysis of Reelin signaling pathways.
Investigating tyrosine phosphorylation events induced by Reelin.
Examining the localization of ion channels in neuronal dendrites.

Main Results:

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Last Updated: Apr 20, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

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Published on: April 3, 2013

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

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Published on: March 17, 2014

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Published on: March 8, 2010

Reelin signaling is implicated in specifying dendritic compartmentalization.

Reelin-induced tyrosine phosphorylation drives the enrichment of ion channels in dendritic tufts.

This mechanism contributes to the functional specialization of neuronal compartments.

Conclusions:

Reelin signaling plays a dual role in brain development, influencing both neuronal migration and dendritic structure.
The findings reveal a new mechanism by which Reelin regulates neuronal function through ion channel distribution.