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Updated: Apr 20, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Cholesterol and fat lowering with hydrophobic polysaccharide derivatives
Jana Čopíková1, Tomáš Taubner1, Jan Tůma1
1Department of Carbohydrate Chemistry and Technology, ICT Prague, Technická 5, Prague 6 Dejvice 166 28, Czech Republic.
Abstract:
Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
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