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[Amyloidosis complicating spondyloarthropathies: Study of 15 cases]
Samantha Rodríguez-Muguruza1, Melania Martínez-Morillo1, Susana Holgado1
1Servicio de Reumatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
Background And Objective:
Secondary amyloidosis (AA) is a rare complication of rheumatic diseases.
Objective:
The aim of this study was to determine the frequency of symptomatic amyloidosis AA in patients with spondyloarthropathy.
Patients And Method:
Retrospective study (1984-2013). We reviewed the medical records of patients with spondyloarthropathy who had a histological diagnosis of amyloidosis AA (15 patients).
Results:
We identified 1.125 patients with spondyloarthropathies. Fifteen (1.3%) patients with amyloidosis AA were recruited. It was suspected in 14 patients (93.3%) because of nephrotic syndrome in most of them: 14 were symptomatic (93.3%): 5 (33.3%) ankylosing spondylitis (AS), 5 (33.3%) spondylitis associated with inflammatory bowel diseases (IBD), 4 (26.7%) psoriatic arthritis, and one (6.7%) reactive arthritis. The mean disease duration was 23.9 years. Mortality after one and 5 years of follow-up was 30 and 50% respectively.
Conclusions:
The frequency of clinical amyloidosis AA in our patients was 1.3%. There was a marked male predominance, with AS or IBD. Clinical amyloidosis was diagnosed at a relatively late stage in spondyloarthropathy.
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