Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

943
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
943
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

762
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
762
Drug Discovery: Overview01:26

Drug Discovery: Overview

13.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
13.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

12.0K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

4‑Aminoalkylquinolines as Potent Antitubercular Agents Targeting the Cytochrome bc<sub>1</sub> Complex.

ACS medicinal chemistry letters·2026
Same author

Guanilated Quinolones with Dual Antitubercular and Anti-Inflammatory Activities.

ChemMedChem·2026
Same author

A copper uptake ABC transport system is essential for <i>Mycobacterium tuberculosis</i> virulence.

Emerging microbes & infections·2026
Same author

Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitors.

European journal of medicinal chemistry·2026
Same author

Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation.

EMBO molecular medicine·2026
Same author

Discovery of highly potent α-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of <i>Mycobacterium tuberculosis</i>.

European journal of medicinal chemistry reports·2026
Same journal

Host-derived proteomic biomarkers for discriminating the tuberculosis disease spectrum in a Brazilian cohort.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association between gut microbiota and white matter microstructural damage in tuberculous meningitis patients.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Discovery and identification of a handwritten laboratory notebook by Albert Calmette and Camille Guérin describing experimental studies and development of the BCG vaccine for tuberculosis at the Institut Pasteur.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Delineating the potential of bioenergetics in drug discovery against Mycobacteriumabscessus.

Tuberculosis (Edinburgh, Scotland)·2026
Same journal

Association of vitamin D status with the immune response in active pulmonary tuberculosis patients with chronic pulmonary aspergillosis.

Tuberculosis (Edinburgh, Scotland)·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.3K

Future target-based drug discovery for tuberculosis?

Bavesh Davandra Kana, Petros C Karakousis, Tanya Parish

    Tuberculosis (Edinburgh, Scotland)
    |December 3, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Developing new tuberculosis (TB) drugs requires understanding Mycobacterium tuberculosis metabolism and identifying ideal drug targets. Key target properties include essentiality, druggability, and reduced resistance evolution for effective TB control.

    More Related Videos

    A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
    10:29

    A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

    Published on: March 24, 2017

    8.4K
    An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
    09:34

    An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

    Published on: August 16, 2021

    2.4K

    Related Experiment Videos

    Last Updated: Apr 20, 2026

    System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
    09:57

    System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

    Published on: April 5, 2017

    9.3K
    A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
    10:29

    A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

    Published on: March 24, 2017

    8.4K
    An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
    09:34

    An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

    Published on: August 16, 2021

    2.4K

    Area of Science:

    • Microbiology and Infectious Diseases
    • Drug Discovery and Development
    • Mycobacterial Metabolism

    Background:

    • Urgent need for new tuberculosis (TB) drugs effective against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
    • Current TB drug development is hindered by poor understanding of Mycobacterium tuberculosis metabolism and limited chemical diversity.
    • Traditional biochemical, target-driven approaches have been largely replaced by whole-cell screening methods.

    Purpose of the Study:

    • To discuss challenges in identifying and validating drug targets for Mycobacterium tuberculosis.
    • To highlight key properties of promising drug targets for TB treatment.
    • To inform future drug discovery efforts by consolidating knowledge from recent TB drug development experiences.

    Main Methods:

    • Review of current literature and recent drug development approaches for tuberculosis.
    • Analysis of properties that define effective drug targets against Mycobacterium tuberculosis.
    • Discussion of target essentiality, druggability, resistance evolution, and cellular location.

    Main Results:

    • The effectiveness of drug screening is influenced by the ability to identify compounds that kill Mycobacterium tuberculosis.
    • Key properties for promising drug targets include essentiality for growth, vulnerability, druggability, low resistance evolution potential, and accessibility.
    • Recent drug development successes and failures provide insights into target selection and validation.

    Conclusions:

    • A deeper understanding of mycobacterial metabolism is crucial for developing novel TB therapeutics.
    • Defining and validating drug targets with specific properties can improve the success rate of TB drug discovery.
    • Consolidating experiences from past and ongoing drug development efforts is vital for future TB control strategies.