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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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Quinoline: a promising antitubercular target.

Rangappa S Keri1, Siddappa A Patil1

  • 1Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Jakkasandra post, Kanakapura Road, Ramanagara District, Karnataka 562112, India.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
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Summary
This summary is machine-generated.

Tuberculosis (TB) treatment needs new strategies due to antibiotic resistance. Quinoline compounds show promise as novel anti-TB drugs with diverse structures and mechanisms.

Keywords:
Anti-tubercularMedicinal chemistryMycobacterium tuberculosisQuinolineSynthesisTubercle Bacillus

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Antimicrobial Agents

Background:

  • Tuberculosis (TB) remains a significant global health issue caused by Mycobacterium tuberculosis.
  • Current TB treatment relies on a 50-year-old multidrug regimen, facing challenges from antibiotic resistance.
  • There is an urgent need for novel therapeutic strategies and drug molecules with new targets and mechanisms of action.

Purpose of the Study:

  • To review the latest information on quinoline-based compounds for tuberculosis treatment.
  • To explore the therapeutic potential of quinoline derivatives in combating Mycobacterium tuberculosis.
  • To provide insights for the rational design of new, effective, and less toxic anti-TB drugs.

Main Methods:

  • Literature review of published reports on quinoline compounds and their anti-TB activity.
  • Analysis of the synthetic versatility of the quinoline core for generating diverse derivatives.
  • Collating information on the biological and biochemical activities of quinoline-based molecules.

Main Results:

  • Quinoline compounds are identified as privileged structures in medicinal chemistry with significant anti-TB activity.
  • The synthetic flexibility of quinoline allows for the creation of a wide array of structurally diverse derivatives.
  • Certain quinoline-based compounds have demonstrated potent efficacy against Mycobacterium tuberculosis.

Conclusions:

  • Quinoline derivatives represent a promising scaffold for developing novel anti-TB therapeutics.
  • Further research into quinoline-based compounds is crucial for addressing multidrug-resistant tuberculosis.
  • This review aims to guide future drug design efforts for more active and safer anti-TB agents.