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Personalized medicine in children with asthma
Mariëlle W Pijnenburg1, Stanley Szefler2
1Department of Paediatrics/ Paediatric Respiratory Medicine, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.
Paediatric Respiratory Reviews
|December 3, 2014
Summary
Personalized medicine for pediatric asthma offers tailored treatment for better control and fewer side effects. Pharmacogenetics and e-health show promise, but more research is needed for widespread clinical use.
Area of Science:
- Pediatric Pulmonology
- Clinical Pharmacology
- Biomarker Research
Background:
- Personalized medicine in pediatric asthma aims for tailored management.
- Predicting treatment response using patient characteristics, lung function, and biomarkers is crucial.
- Pharmacogenetics offers potential for personalized asthma therapy due to genetic influences on drug response.
Purpose of the Study:
- To review the current state and future directions of personalized medicine for children with asthma.
- To identify key patient characteristics, biomarkers, and genetic factors influencing asthma treatment.
- To explore the role of e-health interventions in managing pediatric asthma.
Main Methods:
- Review of existing literature on personalized medicine, pharmacogenetics, and biomarkers in pediatric asthma.
- Analysis of studies predicting treatment response and medication reduction.
- Evaluation of the clinical applicability of exhaled breath biomarkers and e-health interventions.
Main Results:
- Several patient factors and biomarkers can predict asthma treatment response and medication reduction.
- Pharmacogenetics is a key area, though limited gene identification and lack of RCTs are barriers.
- Fraction of exhaled nitric oxide is a validated biomarker; e-health interventions show non-inferiority to usual care.
Conclusions:
- Personalized medicine can improve asthma control, reduce adverse events, and potentially lower costs in children.
- Further research is essential to identify more genetic markers and validate biomarkers for clinical use.
- E-health and refined biomarker strategies are expected to advance personalized asthma management in pediatrics.
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