Altered default mode network functional connectivity in schizotypal personality disorder
Qing Zhang1, Jing Shen2, Jianlin Wu1
1Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China; Tianjin Medical University, Tianjin, China.
Schizophrenia Research
|December 3, 2014
Summary
Schizotypal personality disorder (SPD) shows altered default mode network (DMN) functional connectivity, with decreased frontal connectivity and increased temporal/sub-lobar connectivity. These DMN changes may offer insights into schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- The default mode network (DMN) is crucial in various mental disorders.
- DMN abnormalities in schizotypal personality disorder (SPD) remain under-investigated.
Purpose of the Study:
- To investigate alterations in DMN functional connectivity in individuals with SPD.
- To compare DMN connectivity between SPD patients and healthy controls.
Main Methods:
- Independent Component Analysis (ICA) was employed to analyze DMN functional connectivity.
- Study included 18 male SPD patients and 18 age/gender-matched healthy male controls.
Main Results:
- SPD subjects exhibited decreased frontal DMN connectivity (superior/medial frontal gyrus).
- SPD subjects showed increased DMN connectivity in bilateral superior temporal gyrus, putamen, and caudate.
- Healthy controls displayed greater cerebellar activation compared to SPD subjects.
Conclusions:
- DMN functional connectivity, especially in cognitive and emotional regulation areas, is altered in SPD.
- These findings suggest DMN alterations in SPD may be relevant for understanding schizophrenia.
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