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Transfusion-related acute lung injury in paediatric surgical patients: a retrospective study
1Anaesthesia Department, ShengJing Hospital of China Medical University, Shenyang, China.
Insights
Transfusion-related acute lung injury (TRALI) is under-recognized in Chinese children. This study found a low incidence, but longer transfusion times and more female donors were linked to TRALI cases.
Area of Science:
- Pediatric Critical Care Medicine
- Transfusion Medicine
- Pulmonary Medicine
Background:
- Transfusion-related acute lung injury (TRALI) is a rare but serious complication of blood transfusions.
- Limited data exists on TRALI incidence and risk factors in pediatric populations in China.
Purpose of the Study:
- To determine the incidence of TRALI in pediatric patients (age <14 years) in China.
- To identify potential risk factors associated with TRALI in this demographic.
Main Methods:
- Retrospective review of medical records at Sheng Jing Hospital from January 2008 to December 2011.
- Inclusion criteria: pediatric surgical patients with clinical diagnosis of acute lung injury.
- Data collected: transfusion details, sepsis, aspiration, and TRALI diagnosis.
Main Results:
- 1495 patients were reviewed; 35 met criteria for acute lung injury, pulmonary edema, and respiratory distress.
- TRALI was confirmed in 2 cases, yielding a low incidence rate.
- Significantly longer transfusion duration and a higher percentage of female donors were observed in TRALI patients compared to controls.
Conclusions:
- The incidence of TRALI in Chinese pediatric patients appears lower than previously reported.
- TRALI may be under-recognized, under-reported, and undertreated in this population.
- Transfusion duration and donor sex are potential factors warranting further investigation.
Background:
Little is known about the occurrence of transfusion-related acute lung injury(TRALI) in Chinese paediatric patients. As such, a retrospective review of medical records from January 2008 to December 2011 was undertaken.
Objective:
To determine the incidence of TRALI and its risk factors in children (age <14 years).
Study Design And Methods:
All medical records of Sheng Jing Hospital from January 2008 to December 2011 were reviewed retrospectively using the hospital’s record system. Paediatric surgical patients who had been diagnosed clinically with acute lung injury were included. Transfusion data were collected, together with risk factors such as sepsis and aspiration.
Results:
In total, 1495 patients were involved in the study. Thirty-five cases were analysed further as they had acute lung injury, pulmonary oedema and respiratory distress. TRALI was confirmed in two of these cases. The average duration of transfusion was found to be significantly longer in patients with TRALI compared with controls, and the percentage of female donors was significantly higher for patients with TRALI.
Conclusion:
The incidence of TRALI was found to be lower than reported previously, but TRALI is under-recognised, under-reported and undertreated.
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