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Updated: Apr 20, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Nitrous oxide for pain management of first trimester surgical abortion -- a randomized controlled pilot study
Rameet H Singh1, Eve Espey1, Shannon Carr1
1University of New Mexico School of Medicine Department of Obstetrics and Gynecology, Albuquerque, New Mexico.
Objective:
The objective was to determine feasibility of a study comparing mean pain scores between women randomized to nitrous oxide/oxygen (NO) versus oxygen+oral analgesics for trimester surgical abortion.
Study Design:
Pilot randomized controlled trial comparing NO (n=10) versus oxygen+oral analgesics (n=10). Feasibility of subject recruitment, and pain and satisfaction scores on a visual analog scale were evaluated.
Results:
Fifty-seven percent of eligible women participated. Mean pain scores were similar between groups, and mean satisfaction scores were higher for the NO group (77.5 vs. 46.7, P=.048).
Conclusions:
The majority of eligible women agreed to participate in this study evaluating an uncommon pain control intervention.
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