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Drug delivery in aortic valve tissue engineering.

Soumen Jana1, Robert D Simari2, Daniel B Spoon1

  • 1Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 3, 2014
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Tissue engineering offers a promising approach to create improved heart valve replacements. This review explores using biological signals to enhance engineered heart valves, overcoming limitations of current prostheses.

Keywords:
Drug deliveryFiberHeart valveHydrogelScaffoldTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Current heart valve prostheses (mechanical and biological) have limitations including thrombogenicity, durability issues, and inability to grow or remodel.
  • Heart valve tissue engineering aims to create functional biological valve substitutes.
  • Existing tissue engineering strategies involve delivering scaffolds and cells, but require further enhancement.

Purpose of the Study:

  • To review the delivery of biological reagents for guiding and regulating heart valve tissue engineering.
  • To highlight methods for functional enhancement of engineered heart valve matrices.
  • To discuss strategies for overcoming limitations of current prosthetic heart valves.

Main Methods:

  • Review of current literature on heart valve tissue engineering.
  • Analysis of strategies for incorporating biological signals into engineered matrices.
  • Exploration of methods for controlled delivery of reagents to cells within scaffolds.

Main Results:

  • Tissue engineering provides a viable alternative to current heart valve prostheses.
  • Controlled delivery of biological signals can augment tissue regeneration and valve function.
  • Enhancing matrices with biological cues offers potential for improved valve remodeling and growth.

Conclusions:

  • Heart valve tissue engineering holds significant promise for developing superior valve substitutes.
  • The controlled delivery of biological reagents is a key strategy to enhance engineered heart valve development.
  • Further research in this area could lead to next-generation cardiac repair solutions.