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Prognostic value of RV function before and after lung transplantation
Kenya Kusunose1, Rayji S Tsutsui2, Kavita Bhatt3
1Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
JACC. Cardiovascular Imaging
|December 3, 2014
Summary
Lung transplantation improves right ventricular (RV) function and pulmonary artery pressure. Post-transplant RV function and pulmonary artery pressure predict mortality in lung transplant recipients, enhancing survival prediction models.
Area of Science:
- Cardiology and Thoracic Surgery
- Pulmonary Medicine
- Transplantation Science
Background:
- Lung transplantation outcomes are improving but remain challenging.
- Predictors of mortality are crucial for enhancing long-term survival in lung transplant recipients.
Purpose of the Study:
- To investigate the impact of lung transplantation on right ventricular (RV) function.
- To determine the prognostic value of pre- and post-transplantation RV function in predicting mortality.
Main Methods:
- Eighty-nine lung transplant recipients underwent pre- and post-transplantation echocardiography.
- Left ventricular (LV) and RV longitudinal strains were analyzed using velocity vector imaging.
- Cox proportional hazard models were used to predict all-cause death.
Main Results:
- Post-transplantation, systolic pulmonary artery pressure (SPAP) improved, and RV strain showed enhancement.
- Pre-transplantation RV function did not predict mortality.
- Post-transplantation RV strain and SPAP were independent predictors of all-cause mortality, significantly improving predictive model accuracy.
Conclusions:
- Lung transplantation normalizes RV function and pulmonary artery pressure.
- Post-transplantation RV function serves as a valuable prognostic indicator.
- Larger prospective studies are recommended to validate these findings.
