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Published on: August 20, 2012
A selective fluorescent and colorimetric dual-responses chemosensor for streptomycin based on polythiophene
Minhuan Lan1, Weimin Liu2, Jiechao Ge2
1Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China; Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong Special Administrative Region.
Abstract:
A colorimetric and fluorescent dual-responses chemosensor (PT3, a water-soluble polythiophene) for streptomycin was designed and synthesized. The structure of PT3 was characterized by using infrared spectroscopy, (1)H NMR and gel-permeation chromatography analyses. The conformational change of PT3 induced by streptomycin resulted in the red shift of absorption spectra and fluorescent quenching. Moreover, PT3 showed excellent selectivity for streptomycin over other antibiotics and biomolecules. PT3 could quantificationally detect streptomycin in the range of 2-70 μM with a detection limit of 0.2 μM (116 ppb), which is lower than the maximum residue limit defined by World Health Organization (200 ppb).
