Related Experiment Video
Updated: Apr 20, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
13.8K
Guidelines for treatment of chronic primary angle-closure glaucoma
F J Muñoz-Negrete1, J González-Martín-Moro2, P Casas-Llera3
1Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, OFTARED, Alcalá de Henares, Madrid, España.
Archivos De La Sociedad Espanola De Oftalmologia
|December 3, 2014
Summary
This guideline update reviews medical, laser, and surgical treatments for adult primary angle closure glaucoma (PACG). It provides evidence-based recommendations, acknowledging limitations in study populations and outcome measures.
Area of Science:
- Ophthalmology
- Glaucoma Research
Background:
- Primary angle closure glaucoma (PACG) is a significant cause of vision loss.
- Existing treatment guidelines require regular updates based on new evidence.
Purpose of the Study:
- To provide an updated clinical practice guideline for the medical, laser, and surgical management of adult PACG.
- To synthesize current evidence and establish recommendations for PACG treatment.
Main Methods:
- Systematic literature review using PICO framework.
- Quality assessment of studies using AMSTAR and Risk of Bias tools.
- Evidence grading following the Scottish Intercollegiate Guidelines Network (SIGN) system.
Main Results:
- Presents updated recommendations for medical, laser, and surgical interventions in adult PACG.
- Details the levels of evidence supporting each recommendation.
Conclusions:
- Updated treatment recommendations for adult PACG are provided, despite limitations in evidence quality and applicability.
- Highlights the need for broader research considering visual function, quality of life, and cost-effectiveness, beyond intraocular pressure reduction.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
01:23Ophthalmic Drug Delivery Systems
256
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
256