Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

73
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
73
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.8K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.8K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Rh Blood Group01:19

Rh Blood Group

4.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.6K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

392
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
392

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oseltamivir drug-disease modelling in infants with influenza virus infection.

British journal of clinical pharmacology·2026
Same author

Molnupiravir Treatment Associated With Clearance of Cache Valley Virus From Cerebrospinal Fluid in an Immunocompromised Child With Meningoencephalitis.

Open forum infectious diseases·2026
Same author

Advancements and Uncertainties in the Treatment of Congenital CMV Disease.

Reviews in medical virology·2025
Same author

Influenza Antiviral Pharmacokinetic-Pharmacodynamic Relationships in Pregnancy, Infancy, and Early Childhood.

The Journal of infectious diseases·2025
Same author

Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study.

The Journal of infectious diseases·2025
Same author

Advancements and potential in the prevention of congenital CMV infection.

Seminars in fetal & neonatal medicine·2025

Related Experiment Video

Updated: Apr 20, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.9K

Preventing herpes simplex virus in the newborn.

Swetha G Pinninti1, David W Kimberlin2

  • 1Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue South, CHB 308, Birmingham, AL 35233, USA.

Clinics in Perinatology
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Maternal genital herpes simplex virus (HSV) infections pose a risk to newborns. This review covers neonatal HSV epidemiology, management, and prevention strategies to protect infants from this serious infection.

Keywords:
AcyclovirAntiviral therapyGenital herpesHSVPCR

More Related Videos

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

18.2K
Isolation of Lymphocytes from Mouse Genital Tract Mucosa
04:46

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Published on: September 3, 2012

15.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.9K
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

18.2K
Isolation of Lymphocytes from Mouse Genital Tract Mucosa
04:46

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Published on: September 3, 2012

15.1K

Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Infectious Diseases

Background:

  • Genital herpes simplex virus (HSV) infections are highly prevalent globally, affecting approximately 22% of pregnant women, many unknowingly.
  • Maternal genital herpes is a significant risk factor for neonatal herpes simplex virus (HSV) disease, a serious condition for newborns.
  • Despite being uncommon, neonatal HSV infections are a critical consideration in the differential diagnosis of critically ill neonates due to high morbidity and mortality.

Purpose of the Study:

  • To review the current epidemiology of neonatal HSV infections.
  • To outline the established management protocols for neonatal HSV infections.
  • To discuss effective strategies for preventing HSV transmission from mother to newborn.

Main Methods:

  • This review synthesizes existing literature on neonatal herpes simplex virus (HSV) infections.
  • Epidemiological data on maternal and neonatal HSV prevalence were analyzed.
  • Current clinical guidelines and research on HSV management and prevention were evaluated.

Main Results:

  • Neonatal herpes simplex virus (HSV) disease, while uncommon, carries substantial risks.
  • Effective management and timely intervention are crucial for improving outcomes in affected neonates.
  • Preventive measures targeting maternal HSV infection are essential for reducing neonatal cases.

Conclusions:

  • Neonatal herpes simplex virus (HSV) infections require vigilant diagnosis and management.
  • Implementing robust prevention strategies is key to reducing the incidence of neonatal HSV disease.
  • Continued research is needed to further refine prevention and treatment approaches for neonatal HSV.