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Gestational changes of GABA levels and GABA binding in the human uterus
S L Erdö1, P Villányi, A László
1Department of Anatomy, Georg-August-University, Göttingen, FRG.
Life Sciences
|January 1, 1989
Abstract:
The concentrations of gamma-aminobutyric acid (GABA), the activities of L-glutamate decarboxylase and GABA-transaminase, and the nature of the sodium-independent binding of GABA were examined in uterine tissue pieces obtained surgically from pregnant and non-pregnant women. GABA concentrations were reduced, while the activity of GABA-transaminase and the specific binding of [3H]GABA significantly increased in specimens from pregnant subjects. These findings suggest some gestation-related functional role for the GABA system in the human uterus.