Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

351
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
351
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

310
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
310
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

425
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
425
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.5K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.5K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

642
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
642

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac Amyloidosis: An Updated Review With Emphasis on Diagnosis and Future Directions.

Current problems in cardiology·2017
Same author

Cardiorespiratory Fitness and Health Outcomes: A Call to Standardize Fitness Categories.

Mayo Clinic proceedings·2017
Same author

Survival of the Fittest-Promoting Fitness Throughout the Life Span.

Mayo Clinic proceedings·2017
Same author

Four Years as Editor-in-Chief.

Progress in cardiovascular diseases·2017
Same author

Vitamin D Metabolism and the Implications for Atherosclerosis.

Advances in experimental medicine and biology·2017
Same author

Duration of Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Current problems in cardiology·2017

Related Experiment Video

Updated: Apr 20, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.5K

Changing the endpoints for determining effective obesity management.

Robert Ross1, Steve Blair2, Louise de Lannoy3

  • 1School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada; School of Medicine, Department of Endocrinology and Metabolism, Queen's University, Kingston, Ontario, Canada.

Progress in Cardiovascular Diseases
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Focusing on healthy behaviors like diet and exercise, rather than just weight loss, is key for effective obesity management. Improving physical activity and nutrition can enhance health even without significant weight reduction.

Keywords:
DietExerciseObesityPhysical activityWeight loss

More Related Videos

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

1.9K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.5K

Related Experiment Videos

Last Updated: Apr 20, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.5K
An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

1.9K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.5K

Area of Science:

  • Public Health
  • Behavioral Medicine
  • Obesity Research

Background:

  • Obesity prevalence continues to rise globally despite widespread recommendations for weight loss.
  • Current strategies focusing primarily on weight loss have limited long-term success in combating the obesity epidemic.

Purpose of the Study:

  • To advocate for a paradigm shift in obesity management strategies.
  • To propose focusing on causal behaviors (diet and physical activity) instead of solely on weight loss as the primary endpoint.

Main Methods:

  • Review and synthesis of existing research on obesity management and behavioral interventions.
  • Analysis of the relationship between physical activity, diet, and health outcomes.

Main Results:

  • Increased physical activity (PA) and balanced diets are linked to improved intermediate risk factors for obesity, such as cardiorespiratory fitness (CRF).
  • These improvements can occur independently of significant weight loss.

Conclusions:

  • Effective obesity management requires a focus on improving health behaviors, including diet and physical activity.
  • Prioritizing healthy behaviors may be a more effective short-term strategy for managing obesity and preventing further weight gain.