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Localization of GABAA receptor alpha-subunit mRNAs in relation to receptor subtypes
W Wisden1, B J Morris, M G Darlison
1MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
Brain Research. Molecular Brain Research
|June 1, 1989
Abstract:
The distribution of 3 GABAA receptor alpha-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the alpha 2- and alpha 3-transcripts are of low abundance in all regions except striatum, the alpha 1-transcript is considerably enriched in the inferior colliculus, olfactory bulb and substantia nigra, and appears to be correlated with benzodiazepine type I receptor localization.