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Alginate/sodium caseinate aqueous-core capsules: a pH-responsive matrix.

Ghazi Ben Messaoud1, Laura Sánchez-González1, Adrien Jacquot1

  • 1Laboratoire d'Ingénierie des Biomolécules (LIBio), ENSAIA-UniversitédeLorraine, 2 avenue de la forêt de Haye, TSA 40602, 54518 Vandœuvre-lès-Nancy Cedex, France.

Journal of Colloid and Interface Science
|December 3, 2014
PubMed
Summary

Alginate capsules with sodium caseinate show enhanced mechanical stability and pH-responsive release. This composite system offers control over drug delivery mechanisms for both macro and micro-capsules.

Keywords:
Composite capsulesElectrostatic interactionsMembrane adsorptionSurface Young’s moduluspH-responsive release

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Colloid Science

Background:

  • Alginate capsules are versatile but their properties like permeability and stability are critical for functionality.
  • Modifying alginate capsules with additional components can tune their mechanical and release characteristics.

Purpose of the Study:

  • To investigate the impact of sodium caseinate addition on alginate capsule properties.
  • To explore the influence of preparation pH and sodium caseinate concentration on capsule performance.
  • To understand the mechanism controlling the release kinetics of entrapped substances.

Main Methods:

  • Alginate and alginate-sodium caseinate composite liquid-core capsules were fabricated using extrusion.
  • Physico-chemical properties were analyzed concerning preparation pH and sodium caseinate concentration.
  • Spectroscopic methods (absorbance, fluorescence) were employed to study interactions between sodium caseinate and cochineal red A.

Main Results:

  • Sodium caseinate significantly altered capsule properties, enhancing mechanical stability, particularly at pH below the isoelectric point of sodium caseinate.
  • Composite capsules exhibited pH-responsive release kinetics for cochineal red A.
  • Electrostatic interactions between sodium caseinate and alginate, and between sodium caseinate and the dye, were confirmed, leading to a membrane adsorption release mechanism.

Conclusions:

  • Incorporating sodium caseinate into alginate capsules provides a method to control mechanical strength and release profiles.
  • The study demonstrates a strategy for tuning capsule behavior through molecular interactions for controlled release applications.
  • This approach is applicable to both macro and micro-capsules, offering a versatile platform for drug delivery and other applications.