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Published on: June 21, 2021
Role of sulfiredoxin in systemic diseases influenced by oxidative stress
Asha Ramesh1, Sheeja S Varghese1, Jayakumar Doraiswamy1
1Department of Periodontics, Saveetha Dental College and Hospitals, 162, Poonamallee High Road, Vellappanchavadi, Chennai, Tamil Nadu 600077, India.
Abstract:
Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions.
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