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CC4821 serogroup W meningococcal disease in China

Baohua He1, Zhaoyi Jia1, Haijian Zhou2

  • 1Hebei Province Center for Disease Prevention and Control, No. 97 Huai'an Donglu, Shijiazhuang 050021, Hebei Province, People's Republic of China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|December 3, 2014
PubMed

Insights

Two cases of meningococcal disease caused by rare serogroup W strains (CC4821) were identified in China. This finding is significant as it differs from previously identified invasive serogroup W meningococcal disease strains.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Neisseria meningitidis is a significant global pathogen.
  • Meningococcal disease poses a public health challenge, particularly in China.
  • Serogroup W strains have been infrequently reported in Southeast China.

Observation:

  • Two recent cases of invasive meningococcal disease were documented.
  • The causative agent was identified as Neisseria meningitidis serogroup W.
  • These isolates belonged to the CC4821 sequence type.

Findings:

  • The identified Neisseria meningitidis serogroup W strains were associated with the CC4821 sequence type.
  • This contrasts with previously reported invasive serogroup W meningococcal disease in the region, which involved sequence type 11.
  • This represents a novel finding in the epidemiology of meningococcal disease in China.

Implications:

  • The emergence of CC4821 serogroup W strains necessitates enhanced surveillance for meningococcal disease in China.
  • Understanding the genetic diversity and epidemiological characteristics of Neisseria meningitidis is crucial for effective disease control.
  • These findings may inform future vaccination strategies and public health interventions against meningococcal disease.
Keywords:
CC4821Neisseria meningitidisSerogroup W

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