Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.9K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.9K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.3K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.3K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.3K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

2.4K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
2.4K
Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

34.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluid Shear-Controlled Pro/Anti-Inflammatory Osteomodulatory Construct for Drug-Free Immune Activation Through Cationic Ion Channel Activation.

Advanced healthcare materials·2025
Same author

Effectiveness and Clinical Outcomes of PGT-M Using Karyomapping for Successful Pregnancy and Birth in Various Types of Charcot-Marie-Tooth Disease.

Journal of personalized medicine·2025
Same author

Prevalence of germline <i>BRCA1/2</i> pathogenic variants in unselected Korean patients with HER2-negative metastatic breast cancer: a nationwide prospective study (KCSG BR19-10).

The Lancet regional health. Western Pacific·2025
Same author

2025 Clinical Practice Guidelines for Diabetes Management in Korea: Recommendation of the Korean Diabetes Association.

Diabetes & metabolism journal·2025
Same author

Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery.

Signal transduction and targeted therapy·2025
Same author

Interface-Sensitive Charge Storage and Activation Behavior of Mn(1,3,5-Benzenetricarboxylic Acid (BTC))-Derived Mn<sub>3</sub>O<sub>4</sub>/Carbon Cathodes for Aqueous Zinc-Ion Batteries.

Molecules (Basel, Switzerland)·2025

Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.6K

Innate immunity and epigenetic plasticity in cellular reprogramming.

John P Cooke1, Nazish Sayed1, Jieun Lee2

  • 1Center for Cardiovascular Regeneration, Houston Methodist Research Institute, United States.

Current Opinion in Genetics & Development
|December 3, 2014
PubMed
Summary

Reprogramming somatic cells into pluripotent stem cells requires activating innate immunity. This immune response is crucial for efficient induction of pluripotency and cellular replication.

More Related Videos

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.8K
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.9K

Related Experiment Videos

Last Updated: Apr 20, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.6K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.8K
Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

11.9K

Area of Science:

  • Cell biology
  • Immunology
  • Stem cell research

Background:

  • Somatic cells can be reprogrammed into pluripotent cells with potential for differentiation and indefinite replication.
  • Recent research indicates a link between innate immunity and the efficiency of pluripotency induction.

Purpose of the Study:

  • To investigate the role of innate immunity in the reprogramming of somatic cells to pluripotency.

Main Methods:

  • This study likely involved experimental manipulation of innate immune pathways in somatic cells undergoing reprogramming.
  • Analysis of cellular markers associated with pluripotency and immune activation.

Main Results:

  • Efficient induction of pluripotency in somatic cells is associated with the activation of innate immunity.
  • Innate immune system activation appears to be a necessary component for successful cellular reprogramming.

Conclusions:

  • The findings highlight the critical role of innate immunity in achieving cellular pluripotency.
  • Understanding this connection may lead to improved methods for regenerative medicine and stem cell therapies.