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Updated: Apr 20, 2026
Development of Leishmania Species Strains with Constitutive Expression of eGFP
Published on: April 21, 2023
Tetracycline-inducible gene expression system in Leishmania mexicana
Natalya Kraeva1, Aygul Ishemgulova1, Julius Lukeš2
1Life Science Research Centre, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic.
Abstract:
Here we present a T7-driven, tetracycline-inducible system for protein expression in human pathogen Leishmania mexicana. The gene expression in this strain is tightly regulated and dose- and time-dependent. This system can be widely used by the parasitology community to analyze effects of genes of interest on biology, physiology and virulence of parasites causing cutaneous leishmaniases.
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