Related Experiment Video
Updated: Apr 20, 2026
04:42
Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
1.8K
Self-harm in bipolar disorder: findings from a prospective clinical database
Caroline Clements1, Steve Jones2, Richard Morriss3
1Centre for Mental Health and Risk, Institute of Brain, Behaviour and Mental Health, The University of Manchester, UK.
Journal of Affective Disorders
|December 3, 2014
Summary
Individuals with bipolar disorder who self-harm are at higher risk of repeating self-harm compared to the general population. This increased risk persists even after accounting for known risk factors, suggesting other elements may be involved.
Area of Science:
- Psychiatry
- Clinical Psychology
- Public Health
Background:
- Bipolar disorder is associated with increased risk of suicidal behavior.
- Prospective studies on self-harm in bipolar disorder are limited.
- Understanding self-harm characteristics and outcomes in bipolar disorder is crucial.
Purpose of the Study:
- To describe characteristics of individuals with bipolar disorder who self-harm.
- To assess the repetition risk of self-harm in bipolar disorder patients.
- To compare self-harm patterns in bipolar disorder versus non-bipolar individuals.
Main Methods:
- Nested case-control study utilizing a prospective self-harm database (1997-2010) in Manchester, UK.
- Comparison of characteristics between bipolar disorder cases and non-bipolar controls using conditional logistic regression.
- Survival analyses to assess the outcome of self-harm repetition.
Main Results:
- Bipolar disorder cases (n=103) were significantly more likely to repeat self-harm (58%) than controls (n=515, 25%).
- Higher prevalence of previous self-harm, unemployment, psychiatric service contact, and sleep disturbance in bipolar cases.
- Adjusted hazard ratio for repetition remained elevated in the bipolar group (aHR 1.68; 95% CI; 1.10-2.56).
Conclusions:
- People with bipolar disorder who self-harm face a substantially higher risk of repetition.
- Known risk factors partially explain, but do not fully account for, the elevated repetition risk.
- Factors such as impulsivity may play a significant role in self-harm repetition among bipolar disorder patients.
More Related Videos
09:55Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
13.3K
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
23.7K
Related Concept Videos
01:30Bipolar Disorder
1.5K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.5K
01:25Borderline Personality Disorder
1.1K
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Genetic and Environmental Contributions
Borderline Personality...
1.1K
01:24Mania and Antimanic Drugs: Overview
808
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
808
02:05Self-Presentation: Self-Monitoring and Self-Handicapping
45.3K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
45.3K
01:29Self-Discrepancy and Its Effects
469
Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...
469
01:30Bulimia Nervosa
1.2K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.2K