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Effective treatment of d-penicillamine induced elastosis perforans serpiginosa with ALA-PDT
Duoqin Wang1, Jun Liang1, Jinhua Xu2
1Fudan University, Huashan Hospital, Department of Dermatology, 12 Wulumuqi Zhong Road, Jing'an District, Shanghai 200040, People's Republic of China.
Abstract:
A case of D-penicillamine(DPA) induced elastosis perforans serpiginosa(EPS) in a 32-year-old Chinese man was reported. The presentation lasted two years and was refractory to traditional medical treatment. He was then commenced on 7.6% 5-aminolevulinic acid (ALA) induced photodynamic therapy(PDT) by a LED light of 633 nm at dose levels of 130J/ cm2 for each session with total 3 sessions at one week interval. The patient was tolerated and responded well to this new approach for DPA-induced EPS without any adverse events. The etiology, pathophysiology, natural history, and treatment options for DPA-induced EPS are reviewed, and the authors suggest this method of treatment to be effective and safe for patients of DPA-induced EPS refractory to conventional therapy.
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