Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.5K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.5K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.7K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

17.1K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
17.1K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

10.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.6K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

4.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Antineoplastic Effects of <i>Zataria multiflora</i>: A Systematic Review of Mechanisms, Selectivity, and Synergy.

Food science & nutrition·2026
Same author

Correction: Phenotype Matching of Regular Donors with Transfusion-Dependent Thalassemia Patients; the Role of Alloantibody and Blood Group Profiling.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

Phenotype Matching of Regular Donors with Transfusion-Dependent Thalassemia Patients; the Role of Alloantibody and Blood Group Profiling.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

Comparative evaluation of microfluidic-synthesized nano-niosomes versus liposomal and micro-niosomal deferoxamine in murine iron overload models.

Research in pharmaceutical sciences·2026
Same author

Preliminary screening reveals HPV-derived cDNA in the HNCF-PI 52 cell line originally derived from normal cervical tissue.

Journal of virological methods·2026
Same author

Preclinical and Clinical Evidence on the Efficacy and Cytotoxicity of Curcumin and Curcumin Derivatives in Chronic Myeloid Leukemia: A Systematic Review.

Phytochemical analysis : PCA·2026

Related Experiment Video

Updated: Apr 20, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.1K

Idiopathic lymphocytopenia.

Mehran Gholamin1, Ali Bazi, Mohammad Reza Abbaszadegan

  • 1Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Opinion in Hematology
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Idiopathic CD4⁺ lymphocytopenia (ICL) is a rare condition affecting CD4⁺ T cells. Research highlights its diverse clinical presentations, potential links to cytokines like IL-2, and emerging therapeutic strategies including transplantation.

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K
Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.1K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K
Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

6.1K

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Idiopathic CD4⁺ lymphocytopenia (ICL) is characterized by low CD4⁺ T cell counts without known secondary causes.
  • The condition presents a significant challenge due to limited understanding of its pathogenesis and clinical spectrum.

Purpose of the Study:

  • To review the latest clinical, pathological, and therapeutic data on ICL from 1990 to 2014.
  • To describe ICL's clinical presentations, complications, and potential underlying mechanisms.

Main Methods:

  • Literature review of studies published between 1990 and 2014.
  • Analysis of clinical presentations, pathological findings, and therapeutic interventions in ICL patients.

Main Results:

  • ICL patients face serious complications, including disseminated malignant tumors.
  • Cytokines, particularly interleukin-2, may influence ICL severity and treatment response.
  • Defects in hematopoietic stem cells are suggested as a potential factor, with bone marrow transplantation showing success.

Conclusions:

  • ICL is an increasingly important hematologic condition with a broad clinical and pathological range.
  • Mutations in lymphocyte development and the role of IL-2 are key areas of investigation.
  • Management focuses on infections, underlying disorders, and therapies to increase CD4⁺ counts, such as cytokine treatment and transplantation.