Serum lipid response to dietary cholesterol in subjects fed a low-fat, high-fiber diet

To determine whether hyperresponse to dietary cholesterol occurs in individuals consuming a low-fat diet, a study was performed on 58 subjects whose plasma cholesterol had changed by greater than or equal to 5% when intakes of two and seven eggs per week were compared in a previous study. Here, the effect of eating nine, zero, and nine eggs per week was studied over 3 consecutive months. Plasma total, LDL, and HDL cholesterol did not differ significantly. There was no correlation between individuals' lipoprotein changes in this and the previous study. Consistent hyperresponse to moderate cholesterol intake is not apparent in people eating a low-fat, high-fiber diet. Reduction in dietary cholesterol below 400 mg/d produces no further substantial cholesterol lowering.