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Updated: Apr 20, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
Beyond autonomic neuromodulation: acetylcholinesterase inhibitor against peripheral artery disease
Chang-Ning Hao1, Yi-Qin Shi1, Ze-En Cheng2
1Department of Vascular Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract:
The acetylcholinesterase inhibitor (AChEI)-based therapeutic strategies have been shown to have vasculoprotective properties in the animal model of hindlimb ischemia due to its activation of the endothelial cholinergic system. However, little is know about whether other cell types (myocytes, immunocytes) are involved in the AChEI-related therapeutic benefits in peripheral artery disease. Therefore, we review the multiple cell-targeted effects of AChEI on the animal model of hindlimb ischemia and explore its clinical application in angiomyogenesis.
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