[Automatic measurement of special leaning characteristics in mice during the water Morris maze test with inverted...

The description of the installation with inverted light is given as well as its software EthoStudio, which allows tracking the movements of any color animal in the water Morris maze (WMM) in high definition. The installation is based on the transmitted light technology (inverted light). The software gives possibility to estimate a wide range of learning indices. We have studied the statistic properties of three most widespread indices: latent time of platform finding, covered distance and the sum of distances to the center of the platform. The covered distance has shown the best statistic characteristics if compared to two other indices. The influence of polymorphism C1473G in the gene of the key serotonin synthesis enzyme, tryptophan hydroxylase 2, on the learning abilities of mice in WMM has been studied. Mice of the unique congenic lines B6-1473C and B6-12473G that differ by the polymorphic alleles C1473G have not demonstrated the association between the ability to learn and the genetically determined activity of tryptophan hydroxylase 2 in the brain.