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Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection
S C Harris1, J E Wallace, G Foulds
1Laboratory Service, Audie L. Murphy Memorial Veterans' Hospital, San Antonio, Texas.
Antimicrobial Agents and Chemotherapy
|May 1, 1989
Abstract:
A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.