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Related Concept Videos

Tandem Mass Spectrometry01:21

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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Review on ion mobility spectrometry. Part 1: current instrumentation.

R Cumeras1, E Figueras, C E Davis

  • 1Institut de Microelectrònica de Barcelona, IMB-CNM (CSIC), Esfera UAB, Campus UAB s/n, E-08193 Bellaterra, Barcelona, Spain. eduard.figueras@imb-cnm.csic.es.

The Analyst
|December 4, 2014
PubMed
Summary
This summary is machine-generated.

This review summarizes Ion Mobility Spectrometry (IMS) instrumentation, detailing eight types of devices and their commercial availability. It highlights IMS

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Ion Mobility Spectrometry (IMS) is a established technique for gas-phase ion separation.
  • IMS separates ions based on their mobility within an electric field, with some instruments also using gas flow for temporal separation.

Purpose of the Study:

  • To provide a comprehensive overview of current Ion Mobility Spectrometry instrumentation.
  • To detail the characteristics, hyphenation capabilities (especially with Mass Spectrometry - MS), and commercial availability of various IMS devices.

Main Methods:

  • Review and summarization of eight distinct types of IMS instruments.
  • Comparison of the six most established IMS devices.
  • Identification of IMS instruments compatible with Mass Spectrometry (MS).

Main Results:

  • Detailed description of current IMS instrumentation, including their operational principles.
  • Information on the commercial availability and MS hyphenation potential for each reviewed IMS type.
  • Comparative analysis of the most consolidated IMS devices.

Conclusions:

  • The review offers an insightful perspective on the main characteristics and aspects of IMS technology.
  • It serves as a guide to understanding the landscape of IMS instrumentation and its integration with other techniques like MS.