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Related Experiment Videos

Ultraviolet irradiation for hepatic rickets.

S W Kooh1, E A Roberts, D Fraser

  • 1Department of Paediatrics, University of Toronto, Ontario, Canada.

Archives of Disease in Childhood
|April 1, 1989
PubMed
Summary

Ultraviolet irradiation effectively treats rickets caused by vitamin D deficiency in infants with chronic liver disease. This method corrects biochemical issues and heals rickets, maintaining healthy vitamin D levels.

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Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Endocrinology

Background:

  • Vitamin D deficiency rickets can arise from malabsorption in infants with chronic liver conditions.
  • Hepatobiliary disorders may impair vitamin D metabolism and intestinal absorption.

Observation:

  • Two pediatric patients, one with cytomegalovirus hepatitis and another with Alagille's syndrome, presented with vitamin D deficiency rickets.
  • Both patients exhibited malabsorption as the underlying cause of their rickets.

Findings:

  • Treatment with ultraviolet irradiation successfully corrected biochemical abnormalities associated with vitamin D deficiency.
  • Ultraviolet irradiation led to the healing of rickets in both pediatric patients.
  • Sustained normal 25-hydroxy-vitamin D levels were observed in one infant using a home sunlamp for over a year.

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Implications:

  • Ultraviolet irradiation presents a viable and effective therapeutic option for hepatobiliary rickets.
  • This treatment modality can be a valuable tool in managing vitamin D deficiency in pediatric liver disease.
  • Home-based ultraviolet therapy may offer a long-term solution for maintaining vitamin D sufficiency.