Related Experiment Video
Updated: Apr 20, 2026

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery
Published on: May 11, 2011
A novel in vivo impact device for evaluation of sudden limb loading response
Erin Boutwell1, Rebecca Stine2, Steven Gard1
1Northwestern University Prosthetics-Orthotics Center Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1100, Chicago, IL 60611, USA; Department of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA; Jesse Brown VA Medical Center, Department of Veterans Affairs, 820 South Damen Avenue, Chicago, IL 60612, USA.
Abstract:
The lower limbs are subjected to large impact forces on a daily basis during gait, and ambulators rely on various mechanisms to protect the musculoskeletal system from these potentially damaging shocks. However, it is difficult to assess the efficacy of anatomical mechanisms and potential clinical interventions on impact forces because of limitations of the testing environment. The current paper describes a new in vivo measurement device (sudden loading evaluation device, or SLED) designed to address shortcomings of previous loading protocols. To establish the repeatability and validity of this testing device, reliability and human participant data were collected while the stiffnesses of simulated and prosthetic limbs were systematically varied. The peak impact forces delivered by the SLED ranged from 706±3 N to 2157±32 N during reliability testing and from 784±30 N to 938±18 N with the human participant. The relatively low standard deviations indicate good reliability within the impacts delivered by the SLED, while the magnitude of the loads experienced by the human participant (98-117% BW) were comparable to ground reaction forces during level walking. Thus, the SLED may be valuable as a research tool for investigations of lower-limb impact loading events.

